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The FINGER trial is the first randomized controlled trial showing that it is possible to prevent cognitive decline using a multi-domain lifestyle intervention among older at-risk individuals. The results highlighted the value of addressing multiple dementia risk factors as a strategy to protect brain health, and promote overall health and functioning.


In the past 2-3 decades, China has seen a steady increase in the age-specific prevalence of Alzheimer’s disease and other dementias, along with rapid health transition characterized by the rise of non-communicable chronic diseases driven...


FINGER is a 2-year multi-center randomized controlled trial (intervention study) carried out in Finland (Coordinated by the National Institute of Health and Welfare, Helsinki), in collaboration with Karolinska Institutet (Sweden), testing...


This US-POINTER trial will test a 2-year multi-site and community-based multidomain intervention of physical activity, nutritional guidance, cognitive training and social activities, and management of medical co-morbidities. This project...


The SINGapore intervention study to prevent cognitive impairment and disability (SINGER) initiative aims to initially develop pilot studies of culturally appropriate interventions based on FINGER so as to eventually undertake a large...

MYB trial

The program is based on addressing modifiable risk factors for dementia in general and AD in particular, namely physical inactivity, cognitive inactivity, depression, overweight and obesity, diabetes (type 2), high blood pressure and...


The goal of the MIND-AD trial is to identify effective prevention strategies for AD/dementia tailored to different risk groups. The project is based on experiences and data from 5 ongoing European intervention studies on AD/dementia...

The FINGER model is now being replicated in the United States, Europe, Singapore, and Australia – including populations from a variety of geographical and cultural backgrounds. This worldwide effort, collectively referred to as WW-FINGERS, supports a collaborative network of trials and experienced investigators to facilitate harmonization of research methods, and sharing of experiences and data for maximum global scientific impact.